(1) Laboratory for Research on Biologically Compatible Compounds, Facility of Dental Medicine, University of Monastir, Rue Avicenne, Monsastir 5019, Tunisia.
(2) Department of Biomedical and Biotechnological Sciences, University of Catania, Torre Biologica, Via Santa sofia n. 97, 95125 Catania, Italia.
(3) Department of Medical and Surgery Sciences, University of Catania, 95125, Via Santa sofia n. 78, 95123 Catania Italy.
(4) Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Piazza G. Ceasre, 11, 70124, Bari Italy.
Received: 10 February 2020; Accepted 17 March 2020; Published: 20 March 2020
The in vitro study examined in pheochromocytoma 12 (PC12) cells, whether the biomass form of Hericium erinaceus could exert a protective effect against oxidative stress and apoptosis induced by di(2-ethylhexyl) phthalate (DEHP), a plasticizer known to cause neurotoxicity. The researchers demonstrated that pre-treatment with Hericium erinaceus significantly reduced in force DHEP induced cell death. The researchers further postulated that the protective effect may be attributed to Hericium erinaceus´ ability in:
a) reducing intracellular reactive oxygen species levels,
b) preserving the activity of respiratory complexes and
c) stabilizing the mitochondrial membrane potential.
Additionally, Hericium erinaceus pre-treatment significantly modulated Nrf2 and Nrf2-dependent vitagenes expression, preventing the increase of pro-apoptotic and the decrease of anti-apoptotic markers. Collectively the data provides evidence of new preventive nutritional strategy using Hericium erinaceus against DHEP-induced apoptosis in PC12 cells.
The Hericium erinaceus used in this clinical study was supplied by Mycology Research Laboratories Ltd.
Link to study
https://www.mdpi.com/1422-0067/21/6/2138
Clinical Articles
The following section outlines the clinical papers, posters and proposals that refer to the clinical use of MRL mushroom nutrition products. This information is for healthcare practitioners only and should not be provided to members of the general public.
Full Article
Clinical articles
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Impact of Gastrointestinal Tract on Mushroom Biomass: Deciphering Their Potential on Gut Microbiota Modulation.
Helena Araújo-Rodrigues, Ana Sofia Salsinha, João Bettencourt Relvas, Freni K. Tavaria, Manuela E. Pintado Presented at the the 10th International Human Microbiome Consortium (IHMC) Congress held on June 22-25, 2024 in Rome Italy. -
Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential.
Rosanna Di Paola, Rosalba Siracusa, Roberta Fusco, Marialaura Ontario, Gaetano Cammilleri, Licia Pantano, Maria Scuto, Mario Tomasello, Sestina Spanò, Angela Trovato Salinaro, Ali S. Abdelhameed, Vincenzo Ferrantelli, Antonio Arcidiacono, Tilman Fritsch, Gabriella Lupo, Anna Signorile, Luigi Maiolino, Salvatore Cuzzocrea, and Vittorio Calabrese.
Curr Neuropharmacol 2023 Dec 8. PMID: 38073105
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Mushrooms as Functional Foods for Ménière’s Disease.
Victoria Bell and Tito Horácio Fernandes.
Appl. Sci. 2023, 13, 12348. -
Antioxidants, Hormetic Nutrition, and Autism.
Modafferi Sergio, Lupo Gabriella, Tomasello Mario, Rampulla Francesco, Ontario Marialaura,
Scuto Maria, Trovato Salinaro Angela, Arcidiacono Antonio, Anfuso Carmelina Daniela,
Legmouz Maria, Azzaoui Fatima-Zahra, Palmeri Agostino, Spano’ Sestina, Biamonte Francesca,
Cammilleri Gaetano, Fritsch Tilman, Sidenkova Alena, Calabrese Edward, Wenzel Uwe and Calabrese Vittorio. Curr Neuropharmacol. 2023 Aug 17.