(1) CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
(2) III-Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Coimbra, Portugal
(3) Institute of Pharmacology and Experimental Therapeutics/IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
(4) CNC.IBILI - University of Coimbra, Coimbra, Portugal
(5) Achucarro Basque Center for Neuroscience, Science Park of the University of the Basque Country (UPV/EHU) Leioa, Spain
(6) Ikerbasque Basque Foundation for Science, Bilbao, Bizkaia, Spain
(7) Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal
(8) Ministry of Education, Maputo, Mozambique
(9) Faculty of Veterinary Medicine, Lisbon University, Lisbon, Portugal
(10) Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Italy
(11) ) Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Portugal
A research team, based in the Faculty of Medicine at the University of Coimbra (FMUC) and in the Center for Neuroscience and Cell Biology (CNC), Portugal, has found that feeding adult mice with the mushroom Coriolus versicolor increased the complexity of new neurons (nerve cells) formed in the hippocampus, an area of the brain linked to emotions and memory. This finding may have implications for the development of a disease-modifying therapy to prevent or slow the cognitive decline associated with neurodegenerative diseases.
The researchers discovered that feeding the mice with Coriolus versicolor resulted in a significant increase in the length, volume and arborization (fine branching) of the dendrites (finger-like extensions of the neurons that allow them to communicate with each other) of newly-generated neurons in the hippocampus.
They also discovered that this increased ‘dendritic complexity’ was accompanied by an increase in the levels of the protein β-catenin within these neurons. β-catenin plays a major role in neurogenesis (the development of new neurons) through a process known as Wnt/β-catenin signaling.1,2,3
Thus, the positive effect of Coriolus versicolor on the dendritic complexity of hippocampal newly-generated neurons may be mediated, at least in part, by increased levels of β-catenin and enhanced Wnt/β-catenin signaling. The authors concluded that there is a thus-far unexplored neurogenic potential of Coriolus versicolor supplementation, and that it might represent a preventive strategy for neurological conditions that involve cognitive decline.
Oncotarget. 2018 Aug 31;9(68):32929-32942.
Link to article: https://www.ncbi.nlm.nih.gov/pubmed/30250640
Clinical Articles
The following section outlines the clinical papers, posters and proposals that refer to the clinical use of MRL mushroom nutrition products. This information is for healthcare practitioners only and should not be provided to members of the general public.
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Clinical articles
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Natural Compounds such as Hericium erinaceus and Coriolus versicolor Modulate Neuroinflammation, Oxidative Stress and Lipoxin A4 Expression in Rotenone-Induced Parkinson’s Disease in Mice
Marika Cordaro 1,†, Sergio Modafferi 2,†, Ramona D’Amico 3, Roberta Fusco 3, Tiziana Genovese 3, Alessio Filippo Peritore 3, Enrico Gugliandolo 4, Rosalia Crupi 4, Livia Interdonato 3, Davide Di Paola 3, Daniela Impellizzeri 3,*, Salvatore Cuzzocrea 3,5,*, Vittorio Calabrese 2,*, Rosanna Di Paola 4,‡ and Rosalba Siracusa 3,‡ -
Key Mechanisms and Potential Implications of Hericium erinaceus in NLRP3 Inflammasome Activation by Reactive Oxygen Species during Alzheimer’s Disease
Marika Cordaro 1,† , Angela Trovato Salinaro 2,† , Rosalba Siracusa 3,† , Ramona D’Amico 3 , Daniela Impellizzeri 3 , Maria Scuto 2 , Maria Laura Ontario 2, Salvatore Cuzzocrea 3 , Rosanna Di Paola 3,* , Roberta Fusco 3,‡ and Vittorio Calabrese 2,‡ -
Coriolus Versicolor Downregulates TLR4/NF-B Signaling Cascade in Dinitrobenzenesulfonic Acid-Treated Mice: A Possible Mechanism for the Anti-Colitis Effect
Daniela Impellizzeri 1,† , Roberta Fusco 2,† , Tiziana Genovese 1, Marika Cordaro 3 , Ramona D’Amico 1 , Angela Trovato Salinaro 4 , Maria Laura Ontario 4, Sergio Modafferi 4, Salvatore Cuzzocrea 1,5,* , Rosanna Di Paola 6,* , Vittorio Calabrese 4,‡ and Rosalba Siracusa 1,‡ -
Characterization of bioactive compounds in mushroom biomass of Coriolus versicolor, Hericium erinaceus and Pleurotus ostreatus species
Helena Araújo-Rodrigues, Manuela Amorim, Ana Sofia Salsinha, Sara Marçal, Freni K. Tavaria, João B. Relvas and Manuela E. Pintado. Catolica University, Porto Portugal. Presented at the XXII Congress, European Food ChMemistry Congress (EuroFoodChem) June 14-16, 2023, Belgrade, Serbia.