† Equal contributors
1 Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy
2 Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Messina, Italy

Results indicate that nutritional modulation of critical proteins involved in brain stress tolerance can be achieved via supplementation with a well characterized strain of Hericium erinaceus biomass. These findings are relevant to those theories connecting faulty protein quality control mechanisms with age-associated neurodegenerative diseases